They will serve as a reference standard and assist in the selection of strains for future work. These data illustrate the diversity of body weight and composition in inbred mice. Some of the fattest strains are infrequently used in obesity experiments, for example the JF1/Ms and CBA/J strains. Males were significantly heavier than females in 26 strains and significantly fatter than females in 9 strains only the KK/H1J strain had fatter females than males. In general, heavier strains had a higher %Fat ( r=0.57) but several light strains were also quite fat (e.g., SPRET/EiJ, body weight= 15.7☐.6 g, %Fat=26☑%). The percentage of body weight that was fat (%Fat) ranged from 16±4% (C58/J) to 39☒% (NON/LtJ). There was a nearly continuous range of body weights, from a strain mean±SE of 11.4☐.2 g (MSM/MsJ) to 39.3☑.8 g (NON/LtJ). Carcass lean and fat weights were assessed using a PIXIMus II DEXA and confirmed by fat extraction assay. Body composition was assessed in ~16-wk old mice that had been individually housed and fed a high-carbohydrate, low-fat diet (AIN-76A) for the previous 8 wk. We measured body weight and composition of ~10 male and ~10 female mice from 40 inbred strains.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |